Once you store a Word Document or PDF Document in your database as a BLOB you then need to convert it to a Byte Array in order for the browse to launch Word or Adobe to open the PDF. This example pulls either the Word or PDF version from a table. 

//Select either the Word or PDF version
byte[] ProposalDoc;
string ContentType = string.Empty;
string Extension = string.Empty;

if (asWord)
{
    ProposalDoc = row.PROPOSAL_WORD;
    ContentType = "application/word";
    Extension = ".doc";
}
else
{
    ProposalDoc = row.PROPOSAL_PDF;
    ContentType = "application/pdf";
    Extension = ".pdf";
}

MemoryStream MemStream = new MemoryStream(ProposalDoc);
CTX.Response.ContentType = ContentType;
CTX.Response.AddHeader("content-disposition", 
       "attachment; filename=" + DocumentName + Extension);
//Response.AddHeader("Content-Length", oStream.Length.ToString());

CTX.Response.Clear();
CTX.Response.Buffer = true;
CTX.Response.BinaryWrite(MemStream.ToArray());
CTX.Response.End();            

The ASPOSE document object is not searializeable.  In order to save the object to the database you first have to convert it to a memory from the object (such as PDF of Word). Once you have it in a Byte Array you can updated a BLOB column in the database.

//Convert to WORD
MemoryStream outStream = new MemoryStream();
asposeDocument.Save(outStream, Aspose.Words.SaveFormat.Doc);
byte[] docBytes = outStream.ToArray();

//Convert to PDF
outStream = new MemoryStream();
asposeDocument.Save(outStream, Aspose.Words.SaveFormat.Pdf);
byte[] pdfBytes = outStream.ToArray();